He & She MD Pricing Review: Monthly Plans vs Annual Prepayment

He & She MD's $99 semaglutide headline is an annual-plan equivalent: the listed upfront payment is $1,188. Its monthly semaglutide plan is $199. Tirzepatide is $299 on monthly billing or the equivalent of $159 a month with a $1,908 annual payment. The important choice is therefore both a medication and a billing commitment.¹

This pricing review focuses on the public plans read in October 2026. For the broader service assessment, see our He & She MD provider review.

How do the plans compare?

Semaglutide is listed at $199 monthly, $447 for three months, $834 for six months, or $1,188 annually. Tirzepatide is $299 monthly, $627 for three months, $1,194 for six months, or $1,908 annually. The longer plans reduce the monthly equivalent while requiring a larger payment at once.¹

For example, twelve semaglutide payments at $199 would total $2,388, compared with the listed annual payment of $1,188. That $1,200 difference assumes the monthly price remains unchanged and twelve months of treatment are actually used. An annual commitment is less attractive if you discontinue early and the remaining amount is not refundable.

What does the advertised package include?

The plan page lists medication if prescribed, supplies, free shipping, ongoing support, unlimited messaging, and no membership fees. It says patients are charged only if prescribed. Those statements help with an initial comparison, but obtain the terms that apply to your own order before authorizing a payment.¹

In particular, ask when the prepaid plan begins, how much medication is sent at once, what happens if the dose changes, and whether stopping treatment cancels future charges or also creates a refund. Those are different outcomes. A cancellation button does not necessarily recover money already paid.

When does monthly billing make more sense?

Monthly billing can be easier to budget when you do not yet know whether the treatment suits you. You are paying more for each month, but keeping less money committed to later care. Prepayment can be reasonable when the treatment plan is stable, the terms are clear, and you can afford the upfront amount without depending on a future refund.

Do not choose a longer term simply because the monthly equivalent is lower. Ask the clinician how follow-up will work if you develop side effects or need to change treatment. Our GLP-1 gut-health guide discusses the digestive questions worth raising before you begin.

What else should you verify?

Confirm availability for your state and the pharmacy that would fill your prescription. The advertised price is not a guarantee that every formulation or dose will be available to every patient. Compounded medication is not FDA-approved, and FDA advises discussing whether an approved drug can meet the patient's needs.²

This review does not assess an individual prescriber's performance or establish the quality of a dispensed batch. The public plan table supports a cost comparison; clinical suitability and pharmacy verification require separate answers.

Our assessment

He & She MD gives shoppers a clearly differentiated monthly and prepaid ladder. Use $199 for semaglutide and $299 for tirzepatide when comparing ongoing monthly billing, and show the full upfront payment whenever comparing a longer term. Use our monthly cost calculator to include commitments and compare other GLP-1 telehealth options before deciding.