He & She MD review: $199 a month, or $1,188 up front

He & She MD (heandshemd.com) is prescription telehealth, not a supplement, and it is worth a page here for the same reason the other provider dispatches are: if you are weighing a probiotic against a prescribed GLP-1, you should know what the prescription actually costs and who makes it.

The number on the banner is not the number you pay

Its plan page prices four commitment terms for each molecule and — unusually — puts the amount actually charged beside each one. Semaglutide runs $199 a month paid monthly, then $447 for three months, $834 for six, and $1,188 once for a year — that last rung being the $99 the banners quote. Tirzepatide is the same ladder a rung up: $299 monthly, or $1,908 committed for the year.

Publishing the charged amount beside the monthly equivalent is better disclosure than most of this category manages. The catch is which rung the marketing repeats. Every banner on the site says "from just $99/month", and $99 requires committing a year. The rate that lets you stop after a month is double it.

One trap worth naming: $139 and $99 are semaglutide rates, not tirzepatide. The company's own footnotes mark one promotion "only applies to Tirzepatide" and the other "only applies to Semaglutide". A reader skimming the banners will file the wrong molecule's price — which is exactly what happened on a sibling site of ours for six days before we caught it.

It names its pharmacy, which most will not

Its FAQ gives F&F Pharmacies Inc, doing business as Jungle Jim's Pharmacy, 5484 Dixie Highway, Fairfield, OH 45014, with a phone number. A name, a street address and a number is a disclosure you can act on. Most operators in this batch name no pharmacy at all.

Two qualifiers, because a good disclosure still needs reading. Jungle Jim's turns up behind other storefronts too, so what you learn is who fills the bottle, not something particular to this company. And no compounding classification is stated for it — neither 503A nor 503B appears anywhere on the site.

Where the site argues with itself

A disclaimer states that medication in the GLP-1 program is "produced in USP-compliant, state-regulated pharmacies but not reviewed by the FDA for safety, efficacy, or quality" — accurate, and more forthcoming than most. A block on the homepage above it is headed "FDA-regulated pharmacies". State-regulated and FDA-regulated are not the same claim, and both are live.

On who is behind it: the clinical side is named — Wasef Health, PC c/o Michael Wasef MD, with Dr. Ozita Cooper, MD as chief medical officer — while the storefront itself never names a company, and the address it publishes is a PO Box on a site that refuses to ship to one.

Then the FAQ contradicts the shipping answer three paragraphs above it. The pharmacy it names holds a license in 44 states, not all fifty — California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia and Delaware are excluded — and it cannot dispense sterile compounds. A weekly GLP-1 injection is a sterile compound. A second pharmacy, GoGoMeds, appears in the same answer. Which one fills a GLP-1 order is the question the page raises and does not answer.

Coverage, and what is not priced

GLP-1s ship to every US state except Louisiana, and nothing ships to a PO Box. Longevity and hormone medications ship nationwide.

Worth knowing if you browse further, and corrected here on 15 August after re-reading every page: the rest of the catalog is priced too, on the same four-term ladder as the GLP-1s. NAD+ injectable, NAD+ nasal spray and sermorelin each run $149 a month on a twelve-month plan, $159 on six, $179 on three and $229 month to month. Glutathione is $100 on three months and $125 for one. Lipotropic B12 runs $109 down from $145. Testosterone injections are $119 on a year and $179 month to month; enclomiphene $139 and $189. Every one of those pages advertises the twelve-month rung in its headline, exactly as the weight-loss pages do, so the same rule applies: the advertised number is the one that costs a year up front. The hormone line is the exception that still holds — estradiol patch, gel and pill and the progesterone pill all show "Starting at $125/month" with no term table behind it at all, so what a month actually costs there is the one thing still unpublished. There is no MOTS-c page on the site.

Supplement or prescription

A probiotic works at the margins of appetite and blood-sugar signaling, with modest and realistic effects. A prescribed GLP-1 acts directly on the receptor at pharmacological strength, and the effect size, the side effects and the cost are all in a different league. He & She MD is squarely in the second lane. If you are comparing its numbers against anything on our shelf, compare against $199 and $299 — the month-to-month rungs — rather than the prepaid figures its banners lead with, and against the rest of the field on our best compounded semaglutide and best compounded tirzepatide boards. Read our best metabolic probiotic ranking for the other lane.