Questions, answered with our data
Every figure below is computed from the 31 GLP-1 program reviews and the probiotic ranking behind this site — 31 of those program rows carry a dated verification. Where a company does not publish something, we say so rather than estimate.
This is health information for education, not medical advice — talk to a licensed clinician before starting any probiotic, supplement, or medication.
GLP-1 programs and what they cost
Which GLP-1 telehealth programs publish their price before the medical intake?
30 of the 31 GLP-1 programs we review publish a price a reader can see before handing over any health history, and that question is the heaviest input in our score — a program that prints its number is treating you better than one that gates it behind a quiz, whatever the number turns out to be. Each review states where the figure was read and the date we read it (31 of 31 rows carry a dated verification, the oldest still standing from 2026-08-07).
How much does semaglutide from an online program cost per month?
Counting each program's lowest published monthly semaglutide figure — compounded for most, brand-name where that is all the program sells — the median across the 30 programs we track that publish one is $179 a month, with published figures running from $59 to $1,299. The spread is real: some figures are all-inclusive, some are medication-only with fees on top, and some are prepay rates wearing a per-month label, so every review here reproduces the figure with its conditions attached.
How much does tirzepatide from an online program cost per month?
Counting each program's lowest published monthly tirzepatide figure, the median across the 30 programs we track that publish one is $212 a month, with published figures running from $99 to $399. Tirzepatide consistently costs more than semaglutide at the same seller, and the same caution applies: a figure is only comparable once its billing conditions are read beside it.
Why is the advertised GLP-1 price often not what you pay?
Four patterns account for most of the gap, and we have documented every one on a live program: a mandatory membership fee the medication price excludes; a "per month" figure that is really a 12-month prepay rung, with the walk-away rate much higher; a "1 Month Supply" that bills more often than monthly, so a year holds more than 12 charges; and an intro rate that steps up after the first order. Our reviews lead with the rate you could actually stop paying after one cycle, and print the other rungs beside it.
Access and transparency
Which GLP-1 telehealth programs cover all 50 states?
7 of the 31 programs we review state coverage of all 50 US states on their own pages. Others serve a named subset, and several publish no state list at all — where a program does not publish one, our review says so rather than guessing, and eligibility is worth confirming during intake before any payment.
Do GLP-1 telehealth programs say which pharmacy fills the prescription?
Only 17 of the 31 programs we review publicly name at least one dispensing pharmacy; the rest describe theirs only by category, such as "state-licensed" or "US-based". For a compounded medicine that distinction matters, because the pharmacy — not the telehealth brand — prepares what you inject, and a named pharmacy is one you can look up.
Legitimacy and safety
Is compounded semaglutide or tirzepatide FDA-approved?
No. Compounded semaglutide and tirzepatide are prepared to order by licensed pharmacies and prescribed by licensed clinicians, but they are not FDA-approved finished products and the specific preparation you receive has not been through the FDA's review for safety, effectiveness, or quality. That is the single most important sentence on any page ranking these programs, and it applies to every compounded option we review, including the ones that score highest.
Do any GLP-1 telehealth companies have FDA warning letters?
Yes — 6 of the 31 programs we review are named in an open FDA warning letter, and each of those reviews states that the letter exists, the exact legal entity the FDA addressed it to, and its month and year, with a link to the FDA's own searchable index. We treat a letter as a disclosure rather than a delisting: the program keeps its place and its link, the reader gets the fact, and we never paraphrase what the letter alleges.
The gut side
Can a probiotic do what a GLP-1 drug does?
No. Certain gut bacteria and fermentable fibers can nudge the body's own GLP-1 secretion, and that mechanism is real and worth understanding — but the effect size is nowhere near a pharmaceutical GLP-1 receptor agonist, and no probiotic is a substitute for one. That honesty is this site's editorial spine: the probiotic ranking and the medication reviews are kept separate precisely because a supplement and a prescription drug are different decisions.
Do probiotics actually help with weight loss?
The honest human-trial answer is: modestly, for some strains, and far less than diet, exercise, or medication. A handful of strains — Akkermansia muciniphila, certain Lactobacillus gasseri and Bifidobacterium lactis lines, Hafnia alvei — have randomized human data showing small effects on weight, waist size, or metabolic markers, and our articles separate that human evidence from mechanism and animal data claim by claim.
What is the best probiotic for metabolic health?
Our ranked board's current #1 is CoreAge Rx — GLP-1 Support (From $23.83/bottle), scored on strain evidence, pricing transparency, and value against 6 alternatives — and it is a brand we earn a commission from, which the board discloses beside the pick rather than in a footer. The full scoring, including where the pick loses points, is on the board itself.
About this data
Does a company paying Gut Metabolic change its review?
Payment decides who appears at all — every GLP-1 program with a review here pays us a commission, so this is the set of companies we send readers to, not a survey of the market — but the score itself has no payment input: it is computed from whether the price is published before intake, whether pharmacies are named, billing conditions, and the public record. Unflattering findings about paying partners stay on their pages, including FDA warning letters and prices that double once mandatory fees are counted.
The long versions live in every GLP-1 program review, the metabolic probiotic ranking and the research library. How we earn is set out in our disclosure.